Kpt-330 Clinical Trial

AWARDS ESTABLISHED FOR RESEARCH AND OTHER SPONSORED ACTIVITIES
Performance of circulating tumor cell-endocrine therapy index as Central Laboratory for a Phase I trial of an oral Selective Estrogen REceptor Downregulator in patients with ER positive metastatic breast cancer DANIEL F HAYES (Int Med-Hematology/Oncology) ... Access Full Source

Selective Inhibitors Of Nuclear Export (SINE) As Novel ...
We demonstrate that selective inhibitors of nuclear export (SINE) can functionally inactivate XPO 1 in prostate cancer cells. Unlike the potent, but toxic, XPO 1 inhibitor leptomycin B, SINE inhibitors (KPT-185, KPT-330, and KPT-251) cause a decrease ... View Document

Novel Small Molecule XPO1/CRM1 Inhibitors Induce Nuclear ...
Therapeutic efficacy observed in a phase I clinical trial of intravenous LMB [25], no further trials were conducted using this toxic agent. Recent studies also implicate that XPO1 KPT-330 compound resulted in similar efficacy, where the in vivo ... Return Document

Nashat Y Gabrail, M.D.
2015 - Present Member of CCTA (Coalition of Clinical Trial Awareness) 2015 Selinexor (KPT-330) Demonstrates Broad and Durable Clinical Activity in Relapsed / Refractory Non Hodgkin’s Lymphoma MD,1 4Nashat Y. Gabrail, MD, Hassan Ghazal, MD,3, Donald V. Woytowitz, ... Retrieve Content

Dear Colleagues, Designed To - Northwestern Medicine
February 3, 2015 Dear Colleagues, Please find below details of a high priority clinical study just opened to patient accrual at the Northwestern ... Read Full Source

Aankomen En Open Studies.doc - Erasmus MC
A Phase II study of selinexor (KPT‐330) A Phase IIb, Two‐arm, Randomized, Open‐label Clinical Trial Microsoft Word - aankomen en open studies.doc.docx Author: 404006 Created Date: 9/15/2015 2:00:35 PM ... View This Document

Performance In Initiating Clinical Trials - Q2 2015-16
Performance in Initiating Clinical Trials - Q2 2015-16 Research Ethics Committee Reference Number Name of Trial Date of Receipt of Valid Research ... Document Retrieval

Osuwmcdigital.osu.edu
John C. Byrd, MD May 5, 2015 . JOHN C. BYRD, MD . Office Address: 455 CCC Wiseman Hall, 400 W. 12th Ave, Columbus, OH 43210 . Mailing Address: B305 Starling Loving Hall, 320 West ... Read Document

BTA E-News - Kræftens Bekæmpelse
BTA e-News The monthly bulletin for our international brain tumour community Results from a 20 patient trial showed that nivolumab, either alone or in (KPT-330) shows clinical effect in recurrent glioblastoma ... Retrieve Full Source

Anil K. Sood, M.D., Professor Vice Chair, Translational ...
Vice Chair, Translational Research . Departments of Gynecologic Oncology and Cancer Biology . “POSITION” Trial . Debulking Tissue acquisition Novel therapy . vs. Others: Prolanta (PrL), KPT-330 . ... Read Here

Best Of ASH 2013 - International Myeloma Foundation
Best of ASH 2013 International Myeloma Foundation Selinexor (also known as KPT-330, among main agents going through the clinical trial process. Combinations of recently approved new drugs are also remarkably effective. ... Retrieve Full Source

Novel Reversible Selective Inhibitor Of Nuclear Export Shows ...
Novel reversible selective inhibitor of nuclear export shows that CRM1 is a target in colorectal cancer cells Mingshan Niu1,2,#, The phase I clinical trial of KPT-330 on colorectal cancer patients showed that most patients had stable ... Fetch Doc

C R Cargo M Dr. Anolik Has Served As A Consultant For And M ...
T. Owen, W. Wang, D. McCauley, L. Strojny, J. Hossler, M Kauffman, S. Shacham, J. Rangel-Moreno, and JH. Anolik KPT-330 KPT-330 on U2OS osteosarcoma for 4-24 hours @ 1 mM multiple myeloma in clinical trial Time post dose (hr) 0 5 10 15 20 25 30 0% 20% 40% 80% 100% ... Retrieve Doc

Sarah Cannon Research Institute Has 74 Abstracts Accepted For ...
Sarah Cannon Research Institute has 74 abstracts accepted for presentation at the 2014 ASCO® Annual Meeting advanced cancers to prospectively guide clinical trial selection; the sarah cannon research institute KPT-330 (selinexor) in patients (pts) with heavily pretreated non-Hodgkin's ... Fetch Here

Www.cancercare.on.ca
Systemic treatment funding model definition of a clinical trial will vary based on the trial design, such as the treatment intent and the trial phase. For detailed information around funding for a particular trial, please contact STFM@cancercare.on.ca. ... Doc Viewer

Amonafide Regimen Not Superior To Standard Care In Secondary AML
“On the basis of previous phase I and II clinical trial data and a mechanism of action including the Journal of Clinical Oncology. the nuclear export inhibitor KPT-330, or the BCL-2 antagonist ABT-199.” Page 1 of 2. ... Read Document

Clinical Trials In Myeloma And Related Disorders At PMH
Clinical Trials in Myeloma and Related Disorders at Doses of the Selective Inhibitor of Nuclear Export (SINE) KPT-330 in Patients with Advanced Hematological Malignancies • Inclusions: 1. Written A Phase 1/2 Trial of ASP7487 (ASP7487 (OSI-906) ... Get Content Here

Soy-based Compound May Reduce Tumor Cell Proliferation In ...
Soy-based compound may reduce tumor cell proliferation in colorectal cancer Holcombe and Pintova are launching a clinical trial later this year for patients with metastatic colorectal with KPT-330 had no visible evidence of tumor and ... View Document