Clinical Trial Zfn

HOPE, HYPE & REALITY: ZINC FINGER GENE THERAPY TO CONTROL OR ...
HOPE, HYPE & REALITY: ZINC FINGER GENE THERAPY TO CONTROL OR CURE HIV ZFN-modified T-cells are well tolerated when reinfused and treatment is associated with decreased viral loads in several participants CLINICAL TRIAL RESULTS!!! PART 2 - Duration: 10:14. ... View Video

Efficient Clinical Scale Gene Modification Via Zinc Finger ...
Based on these findings, we initiated a clinical trial testing the safety and feasibility of CCR5 gene-edited CD4+ T-cell transfer in study subjects with HIV-1 infection. research scale untransduced condition and the clinical scale CCR5-ZFN-modified condition in the average percent per- ... Content Retrieval

Human Hematopoietic Stem/progenitor Cells Modified By Zinc ...
Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control evaluated in a clinical trial. However, ZFN-modified CD34+ HSPCs are capable of multi-lineage ... Access Doc

SANGAMO BIOSCIENCES, INC.
United states securities and exchange commission washington, d.c. 20549 form 10-k Í annual report pursuant to section 13 or 15(d) of the securities exchange act ... Document Retrieval

Transcription Activator-Like Effector (TALE) Nucleases And ...
Transcription Activator-Like Effector (TALE) Nucleases HE ZFN a TALEN a CRISPR/ Cas9 to high Low Therapeutic potential: Advantages Naturally occurring endo-nuclease Well established and currently used in HIV clinical trial Engineered to target any sequence with high specificity ... Retrieve Content

Pipeline - Factor IX - Hemophilia.ca
A Phase I clinical trial was planned for 2012 Preclinical trials in mice showed extended half‐life. SB‐FIX ZFN ‐ Microsoft Word - Pipeline - Factor IX.doc Author: craymond Created Date: 12/21/2015 9:25:54 AM ... Retrieve Content

Sangamo BioSciences Presents New Clinical Data At CROI 2015 ...
February 26, 2015 Sangamo BioSciences Presents New Clinical Data at CROI 2015 From Trial of ZFP Therapeutic® Designed to Provide Functional Control of HIV ... Visit Document

Sangamo Presents New Clinical Data At CROI 2013 Demonstrating ...
March 6, 2013 Sangamo Presents New Clinical Data at CROI 2013 Demonstrating Persistent Immune System Improvements After Treatment With ZFN Therapeutic ® SB-728-T ... Fetch Doc

Genome Editing-based HIV Therapies - Cell
Genome editing-based HIV therapies Wan-Gang Gu Department of Immunology, Zunyi Medical University, Zunyi, Guizhou, 563000, China Autologous CD4+ T cells (clinical trial) [42] CCR5 ZFN Autologous CD4+ T cells (clinical trial) [43] CCR5 ZFN Autologous CD4+ T cells (clinical trial) [44] ... Access This Document

Zinc Finger Nuclease - Wikipedia, The Free Encyclopedia
A zinc finger nuclease is a site-specific endonuclease designed to bind and cleave and a clinical trial found CD4+ human T-cells with the CCR5 gene disrupted by zinc finger nucleases to be save Since ZFN-encoding plasmids could be used to transiently express ZFNs to target a DSB to a ... Read Article

Zinc Finger Nuclease-based Stem Cell Therapy For AIDS
Clinical trial . Sangamo BioSciences, Inc . ZFN technology . Michael Holmes PhD Philip Gregory PhD Dale Ando MD . Pre- and Post-clinical studies . CCR5 antagonists – taking a lesson from Nature ... Read Document

What Should Clinical Trials Assessing Cure Look Like?
What Should Clinical Trials Assessing Cure Look Like? Alain Lafeuillade, General Hospital, Toulon, -1 year in Disulfiram trial, >6 months or >3 years in the 2 SAHA trials: Levels of: (ZFN)?-Residual inflammation? Strong Ethical Issues. Accessibility ... View Doc

Pipeline - Factor VIII And VWF - Hemophilia.ca
ZFN ‐mediated Genome Phase I/II clinical trial. The trial will Microsoft Word - Pipeline - Factor VIII and VWF.doc Author: craymond Created Date: 12/21/2015 9:24:59 AM ... Read Document

Regenerative Medicine & Advanced Therapies
Sangamo BioSciences, Inc. announces new clinical data from trial of ZFP therapeutic designed to provide functional control of HIV, also announces FDA acceptance of IND application for new HIV/AIDS clinical trial using ZFN-modification of hematopoietic stem cells - February 26, 2015 ... Access Full Source

trial Watch Novel HIV Gene Therapy Enters Phase I trial
A recent initiation of a Phase i clinical trial highlights a novel genetic approach that aims to make T cells of patients infected with and persistence of Zfn-modified cells, CD4+ cell counts and viral load in patients who have ... Read Content

Genome Engineering At The Dawn Of The Golden Age
(40), corn (124), and tobacco (136), and the first clinical trial of a ZFN was initiated (138). These advances enabled researchers to move beyond knock www.annualreviews.org • Genome Engineering at the Dawn of the Golden Age 155. GG14CH07-Segal ARI 26 July 2013 12 in clinical trial. ... Access Document

PRODUCT PIPELINE - Irish Haemophilia Society
Fc fusion technology binds the FIX molecule to a recombinant human immune globulin molecule to extend half-life. IB1001 Inspiration Recombinant factor IX A Phase III clinical trial was completed in October, ZFN-mediated Sangamo Biosciences Gene therapy for hemophilia B Pre-clinical ... Fetch Document

SANGAMO BIOSCIENCES PRESENTS CLINICAL DATA DEMONSTRATING HIV ...
SANGAMO BIOSCIENCES PRESENTS CLINICAL DATA DEMONSTRATING HIV-infected subjects enrolled in Sangamo’s ongoing SB-728-902 clinical trial (Cohorts 1-3) received ZFN-protected central memory cells are driving positive effects on ... Retrieve Full Source

Zinc Finger Nuclease And Editing The Human Genome: A ...
Zinc Finger Nuclease and Editing the Human Genome: a Molecular Story From the CBM That is exactly what is being done in a Phase 2 clinical trial conducted How do we get the ZFN into the cells? 2. ... Access Doc

Restriction Modification System - Wikipedia, The Free ...
The restriction modification system (RM system) is used by bacteria, and perhaps other prokaryotic organisms, A recent Phase I clinical trial of ZFN for the targeted abolition of the CCR5 co-receptor for HIV-1 has been undertaken [20] Their relation with mobile genetic elements (MGEs) Edit. ... Read Article