Lde225 Clinical Trial

KURZPROTOKOLL - Kompetenznetz-leukaemie.de
LDE225 [ Time Frame: Weekly for the first 9 weeks, Week 11, KURZPROTOKOLL CLDE225X2203. Frankreich Großbritannien Belgien Spanien Italien Niederlande Österreich Norwegen European Clinical Trials Database - EUDRACT2012-004022-21 2 ... Retrieve Full Source

Anna C Pavlick, MS, DO - Research To Practice
She was enrolled on a clinical trial with an investigational hedgehog inhibitor called erismodegib (LDE225). She experienced a 50% reduction in her disease volume, which has lasted for almost a year. What side effects did she experience on erismodegib? ... View Doc

Next Generation Sequencing Assays In Primary And Metastatic ...
Next Generation Sequencing Assays in Primary and Metastatic Breast Cancers: Implications for Clinical Practice Lajos Pusztai, MD, DPhil Professor of Medicine ... Document Viewer

Phase I - Chuv.ch
LDE225 in combination with Paclitaxel in patients with advanced solid tumors. A multicenter phase I trial. ... Access Full Source

MK-3475 And Its Efficacy In Lung Cancer - YouTube
Http://cancerGRACE.org/ Dr. Edward Garon discusses what researchers are learning about MK-3475, an immune therapy treatment currently in clinical trial. February 2014. GRACEcast 198 Lung. ... View Video

205266Orig1s000 - Food And Drug Administration
Safety of two dose levels of LDE225 in patients with locally advancedor metastatic basal cell carcinoma.”Study 2011: End of Phase 1 meeting to discuss the acceptability of a single, clinical trial (Study A2201) evaluating the safety and efficacy two doses of sonidegib (200 mg or 800 ... Document Viewer

Metastatic Triple Negative Breast Cancer: Ongoing Trials
Metastatic Triple Negative Breast Cancer: Ongoing Trials. – Stemness: CXCR4 POL6326 + ct; Notch/Hedgehog RO4929097 + vismodegiv; LDE225 (+BKM120/CT) – Glutaminase Inhibitor: CB-839 – Angiogenesis: • Clinical Benefit 36% (21-57%) ... Access Content

Www.australiansarcomagroup.org
Clinical trial assessing LDE225: A clinical on LD 225 in the treatment of patients with metastatic or un resectable sarcoma read more SUNXRT: A clinical for patients with soft-tissue sarcoma using a approac h of radbtherapy and ... View Doc

Connecting Up - Figshare
Structures and their associated clinical data in the public EP-100, Lu AA21004, LDE225, TC-5619, TPI 287, ACT-129968, XEN402, RO4995855 and FX006. The problem here is that ‘which compounds have (direct) links to clinical trial drug entries’. This is likely to be signifi ... Fetch Document

Novel Targets And Therapies In Clinical Trials For Pancreatic ...
Novel Targets and Therapies in Clinical Trials for Pancreatic Cancer. Maeve Lowery MD. Landmark Phase III Trial APCGemcitabine vs 5-FU. Burris, et al. J Clin Oncol, GDC-0449, IPI-926, LDE225. Von Hoff, D. NEJM, 2009. Thayer, S. Nature, 2003. Feldmann, G. Gut, 2008. Jimeno, A. Mol Can ... Read Here

Inhibition Of Hedgehog Signalling By NVP-LDE225 (Erismodegib ...
Results: NVP-LDE225 cooperated with either everolimus or sunitinib to inhibit proliferation, migration, and invasion of RCC cells even in sunitinib-resistant (SuR) cells. Despite the improved outcomes observed in clinical trials ... Fetch Full Source

Pipeline Of Novartis Oncology 2014-2015 - Ark Media, Inc.
HOW TO GET CLINICAL TRIAL INFORMATION • For countries outside the United States, k Also known as LDE225 l Also known as LGX818 The Novartis Oncology pipeline encompasses a broad spectrum of approaches KEY THERAPEUTIC TARGETS ... Fetch This Document

Vismodegib In Patients With Advanced Basal Cell Carcinoma ...
Background The Hedgehog pathway inhibitor vismodegib has shown clinical benefi t in patients with advanced basal and “LDE225” for peer reviewed papers and abstracts published in the past 5 years label clinical trial of vismodegib as a neoadjuvant to surgery for ... Access Content

Www.ncri-pet.org.uk
A multi-centre Randomised Phase II Clinical Trial Comparing Oxaliplatin (Eloxatin), Capecitabine A Phase I, Multicenter, Open-label, Dose-escalation Study of Oral LDE225 in Patients With Advanced Solid Tumors LDE225 Mount Vernon PARAGON II ... Fetch Doc

Advances In Genomics And Proteomics In Breast Cancer Care
Advances in Genomics and Proteomics in Breast Cancer Care Vered Stearns, M.D. •LDE225 (SMOi) •BGJ398 (FGFRi) •LEE011 (CDK4/6i) •LDK378 (ALKi) –Consider pursuing a clinical trial which targets MEK ... Doc Retrieval

Treatment With Two Different Doses Of Sonidegib In Patients ...
Carcinoma Outcomes with LDE225 Treatment (BOLT) trial was started to assess the safety and antitumour activity of two doses of sonidegib, 200 mg and 800 mg label clinical trial of vismodegib as a neoadjuvant to surgery for high-risk basal cell carcinoma. J Am Acad Dermatol 2014; 71: 904–11. ... Access Full Source

SHORTPROTOCOL - Leukemia Net
Type of Trial multicentric, single-group, prospective, open-label INC424 or LDE225 (e.g., uncontrolled nausea, vomiting, diarrhea; European Clinical Trials Database - EUDRACT2011-005016-28 2 © European Leukemia Information Center ... Retrieve Document

Therapeutic Potential Of Hedgehog Signaling Inhibitors In ...
376 www.future-science.com future science group Therapeutic Perspective Aftab & Rudin Opportunities for evaluating clinical efficacy in adults with advanced metastatic medulloblastoma ... Doc Viewer

Nilotinib - Wikipedia, The Free Encyclopedia
In June 2006, a Phase I clinical trial found nilotinib has a relatively favorable safety profile and shows activity in cases of CML resistant to treatment with imatinib, another tyrosine kinase inhibitor currently used as a first-line treatment. [15] ... Read Article

Novel Treatment Approaches In Pancreatic Cancer
Novel Treatment Approaches in Pancreatic Cancer Janet E. Murphy, MD MPH Clinical trial 13 14 Locally Metastatic Advanced Borderline resectable • Neoadjuvant Gem-Abraxane-LDE225 (Smoothened pathway inhibitor) ... Retrieve Full Source