Yk-4-279 Clinical Trial

From The Laboratory To The clinic - Children's Cancer Foundation
Progress to clinical trial YK-4-279 is given orphan drug status by the US Food and Drug Administration (FDA) under the name Efdispro®. Formulation for human use and toxicology is underway prior to an FDA investigational new drug (IND) application ... Read Full Source

Remaining Challenges In Childhood Cancer And Newer Targeted ...
Childhood Cancer and Newer Targeted Therapeutics Malcolm A. Smith, MD, PhDa,*, Gregory H. Reaman, MDb INTRODUCTION The remaining challenges for childhood cancer research are best understood in the Innovative clinical trials Preclinical testing ... Content Retrieval

Systemic Management Strategies For Metastatic Soft Tissue Sarcoma
Systemic Management Strategies for Metastatic Soft Tissue Sarcoma YK-4-279 7 Low-grade fibromyxoid sarcoma t(7;16)(q33;p11) 28. Cohen MH, Creaven PJ, Tejada F, et al. Phase I clinical trial of isophosphamide (NSC-109724). Cancer Che-mother Rep 1975; 59: 751-5 29. ... View Document

The First European Interdisciplinary Ewing Sarcoma Research ...
REVIEW ARTICLE published: 29 May 2012 doi: 10.3389/fonc.2012.00054 The first European interdisciplinary Ewing sarcoma research summit Heinrich Kovar1,26*, JavierAlonso2, PierreAman3, Dave N.T.Aryee1,26, Jozef Ban1, SueA. ... Fetch Document

Review Article BoneSarcomas:FromBiologytoTargetedTherapies
Review Article BoneSarcomas:FromBiologytoTargetedTherapies NathalieGaspar,1 AngelaDiGiannatale,1 BirgitGeoerger,1 Franc¸oiseRedini,2 NadegeCorradini,` 3 NatachaEnz-Werle,4 FranckTirode,5 PerrineMarec-Berard,6 Clinical development in di ... Read More

Pharmacokinetic Modeling Optimizes Inhibition Of The ...
Pharmacokinetic modeling optimizes inhibition of the -YK-4-279. Efficacious clinical treatment of Ewing sarcoma Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: ... Read Content

Preclinical Tests Shows Agent Stops 'slippery' Proteins From ...
Preclinical tests shows agent stops 'slippery' proteins from binding, causing Ewing sarcoma 15 May 2013 (IND) application for (S)-YK-4-279 so that a clinical trial can be initiated. In the United States, about 500 children and young adults are diagnosed with the cancer annually, and ... Content Retrieval

Potential For Targeted Therapy In Prostate Cancers With ERG ...
Gues,18 the authors hypothesized that YK-4-279, a small molecular inhibitor of EWS-FLI1, from discovery to daily clinical practice. Eur Urol 2009; 56: 275–86. concept trial. Lancet 2010; 376: 245–51. ... Doc Viewer

New Strategies In Ewing Sarcoma: Lost In Translation?
New Strategies in Ewing Sarcoma: Lost in Translation? Fernanda I. Arnaldez and Lee J. Helman have not always been predictive of clinical trial outcomes, Hong SP, et al. Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1. Oncotarget 2012;3: ... Read Here

Systemic Management Strategies For Metastatic Soft Tissue Sarcoma
Systemic Management Strategies for Metastatic Soft Tissue Sarcoma Sujana Movva1 and Claire Verschraegen2 Data from clinical trials including ab YK-4-279 Crizotinib References 3,4 5 6 7 8 ... Retrieve Content

Index [link.springer.com]
522 Index Acute promyelocytic leukaemia (APL) (cont.) anthracycline cumulative dose and cardiotoxicity, 96 arsenic trioxide (ATO) induction and consolidation, 97 ... Get Document